Experimental and parametric studies of a louvered fin and flat tube compact heat exchanger using computational fluid dynamics

AbstractThe present study aimed to perform the parametric analysis on thermo-hydraulic performance of a compact heat exchanger using computational fluid dynamics (CFD). The analysis has been carried out at different frontal air velocities by varying the geometrical parameters such as fin pitch, transverse tube pitch, longitudinal tube pitch, louver pitch and louver angle. The air side performance of the heat exchanger has been evaluated by calculating Colburn factor (j) and Fanning friction factor (f). The comparison of CFD results with the experimental data exhibited a good agreement and the influence of various geometrical parameters for the selected range of values on the pressure drop, heat transfer coefficient and goodness factor was analyzed. The results obtained from the analysis will be very useful to optimize the louvered fin and flat tube compact heat exchanger for better thermo-hydraulic performance analysis without the need of time consuming and expensive experimentation

STUDY ON IN VITRO CYTOTOXICITY OF PAPAIN AGAINST LIVER CANCER CELL LINE HEP G2

Objective: Cancer is a devastating public health problem all over the world. Herbal medicines have a vital role in the prevention and treatment of cancer. Papain is a proteolytic enzyme and a phyto therapeutic agent which highly appreciated in the medical field that prevents several chronic diseases such as cardiovascular disease, cancer and diabetes. The aim of the study describes about the cytotoxicity of papain against liver cancer cell line HepG2. Methods: In different concentrations of samples have been taken for cytotoxicity analysis using the MTT assay and calculate the percentage of cell viability. Results: The 50% inhibition concentration (IC50) of a sample was 125µg/ml and their cell viability percentage was 49.20. The 85% of cytotoxicity has been observed in 1000 µg/ml of papain against HepG2 cell line than other concentrations. Conclusion: 1000 µg/ml of papain has maximum (85%) cytotoxicity effect against liver cancer cell line hepG2

DEVELOPMENT AND COMPARISON OF ORALLY INHALABLE SUSTAINED RELEASE FORMULATIONS FOR THREE RESPIRATORY DRUGS FOR ASTHMA

The present work was designed to develop and compare orally inhalable sustained release formulation for salbutamol sulphate (SS), ambroxol hydrochloride (AH) and montelukast sodium (MS).The emulsion solvent evaporation method was used to prepare microparticles with the polymers. The prepared polymer encapsulated microparticles were blended with carrier inhalable lactose and filled in size 3 hard empty gelatin capsule. Formulations T1-T9 were prepared with 1:1 ratio of PLGA (50:50), PLGA (75:25) and Eudragit RS100. The formulation T1 prepared with SS:PLGA (50:50) produces best result when compared with other formulations T2-T9. Formulation T1 gives in vitro release 91.23% at 12 h and having particle size of microparticles (D0.5 µm) 1.94±0.6 and respiratory fraction 34.9± 2.59 %

Implementation of Improved Method on Embedded Surveillance System with Reduced Power Usage

In this project design and implement a home embedded surveillance system with ultra-low alert power. Traditional surveillance systems suffer from an unnecessary waste of power and the shortcomings of memory conditions in the absence of invasion. In this design we pressure sensors as the alert group in windows and doors where an intruder must pass through. These low-power alert sensors wake up the MCU (Micro Controller Unit) which has power management for the ultrasonic sensors and PIR sensors indoors. This state transition method saves a large number of sensors required for the alert power. We also use the Majority Voting Mechanism (MVM) to manage the sensor groups to enhance the probability of multiple sensors sensing. After the MCU sends the sensor signals to the embedded system, the program starts the Web camera. Our sensing experiment shows that we reduce the system’s power consumption Keywords: Embedded Surveillance System, PIR Sensor, Ultrasonic Sensor, Low-PowerStat

Gynocentrism in Langston Hughes selected poetic works

Gynocentrism exclusive focuses on women both as theory and practice. Anything can be considered gynocentric when it is concerned exclusively with a female point of view. The works of Langston Hughes, which reflect the intersection of races and genders in the lives of blacks, are studied. His contributions take multiple forms including poetry, short stories, dramas and novels which are about black women's love, nature, romantic dilemmas, mother - daughter relationships, friendship, and silences. The authors analyze how gender in a special way colors female identity in Hughes' works. He expresses interdependence of genders and racial identities in his representations of black women and hence can be dubbed as gender racial. His writings are in a gender racial style, highlighting and intertwining gender and racial identities. Hughes' overcomes gender and racial stereotypes with open discussions on contentious themes. It is concluded that Hughes creates an alternative to repressive social realities by combining challenges with sensual visions

Determinants of dysphagia following stroke

Background: Swallowing is affected following stroke. Many studies focus on various aspects of swallowing difficulties (dysphagia) following stroke. However, there are not many studies on the determinants of dysphagia following stroke. The aim of the present study is to establish the association between various factors with the severity of dysphagia.Methods: After screening for Mann Assessment of Swallowing Ability (MASA),110 patients, post-stroke were selected using consecutive sampling to assess the common risk factors, namely the presence of diabetes mellitus, dyslipidemia, hypertension, alcohol usage and smoking habits. Additionally, other variables such as age, gender, type of lesion, side of lesion, tobacco chewing, speech disorders, arterial dysfunction, lobe involvement and Brunnstrom’s stages, were also evaluated using a structured interview method. c2 (chi-squared) analysis was carried out to find out the association between the selected determinants and severity of dysphagia following stroke.Results: It was found that age and Brunnstrom’s stages are the determinants of dysphagia, as analysis showed a strong association with a p value < 0.001. A marginal association between post-stroke dysphagia and type of lesion with a p value of 0.056 was also observed.Conclusions: Among 15 factors evaluated, age, type of lesion and Brunnstrom’s stages showed a significant association with the severity of dysphagia following stroke. This study advocates early dysphagia management for elderly patients with high Brunnstrom’s grading, for those who are not expected to spontaneously recover following stroke, and for earlier and better community rehabilitation. [Ethiop.J. Health Dev. 2019; 33(3):147-152]Key words: Post-stroke dysphagia, Brunnstrom’s stages, dysphagia risk factors

Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor.

Btk and Etk/BMX are Tec-family non-receptor tyrosine kinases. Btk has previously been reported to be expressed primarily in B cells and has an important role in immune responses and B-cell malignancies. Etk has been shown previously to provide a strong survival and metastasis signal in human prostate cancer cells, and to confer androgen independence and drug resistance. While the role of Etk in prostate carcinogenesis is well established, the functions of Btk in prostate cancer have never been investigated, likely due to the perception that Btk is a hematopoietic, but not epithelial, kinase. Herein, we found that Btk is overexpressed in prostate cancer tissues and prostate cancer cells. The level of Btk in prostate cancer tissues correlates with cancer grades. Knockdown of Btk expression selectively inhibits the growth of prostate cancer cells, but not that of the normal prostate epithelial cells, which express very little Btk. Dual inhibition of Btk and Etk has an additive inhibitory effect on prostate cancer cell growth. To explore Btk and Etk as targets for prostate cancer, we developed a small molecule dual inhibitor of Btk and Etk, CTN06. Treatment of PC3 and other prostate cancer cells, but not immortalized prostate epithelial cells with CTN06 resulted in effective cell killing, accompanied by the attenuation of Btk/Etk signals. The killing effect of CTN06 is more potent than that of commonly used inhibitors against Src, Raf/VEGFR and EGFR. CTN06 induces apoptosis as well as autophagy in human prostate cancer cells, and is a chemo-sensitizer for docetaxel (DTX), a standard of care for metastatic prostate cancer patients. CTN06 also impeded the migration of human prostate cancer cells based on a 'wound healing' assay. The anti-cancer effect of CTN06 was further validated in vivo in a PC3 xenograft mouse model

Single Axis Semi Automatic Drilling Machine with PLC Control

ABSTRACT:Under conventionally controlled drilling machine the depth controlled cannot be made possible. Due to over drilling the job gets failed. While drilling we cannot measure the drilling depth during drilling process. Hence the semiautomatic drilling machine will automatically control the depth of the job and it of safer mode. In some cases due to over drilling the work bench will gets destroyed or the tool will be damaged. Hence for these conditions our project work had been taken up to get through the new technologies. This made the drilling machine easier. This semiautomatic drilling machine is very well used in mechanical workshops and it made the work easier. It consumes less time and the finishing process will be quite easier, while compared to the conventional drilling machine